People with paralysis can be at higher risk of developing infections for a variety of reasons.

• Loss of movement and/or sensation: Loss of movement or sensation can make it easier for the affected body part to be injured, such as being cut or burned, and injuries like this may also not be immediately noticed. The longer an injury isn’t noticed, the longer it will take before it is treated. If an infection does set in, it might not be felt or noticed until it has progressed. Decreased movement can also lead to pressure sores that can become infected. Also, decreased or loss of sensation can also make it hard for people to notice that they have an internal infection, such as a urinary tract infection (UTI).
• Inability or difficulty communicating: Some people with paralysis may have difficulty communicating that they feel pain or discomfort from an injury or an infection.
• Presence of other conditions: Depending on what has caused the paralysis and the parts of the body involved, people with paralysis can be at high risk for secondary conditions, such as urinary incontinence (involuntary release of urine) or urine retention (inability to empty the bladder of urine), which can increase their risk of developing a UTI.
• Subtle differences in vital signs. Some people who have paralysis may have unusual fluctuations (differences) in vital signs (pulse, respirations, and blood pressure) from people who do not have paralysis. This may make it harder for healthcare professionals to recognize signs of an infection.

The only way to prevent sepsis is to prevent infections or to treat them as quickly and effectively as possible. Universally, this means:

• Frequent hand washing
• Vaccinations against preventable illnesses
• Prompt identification and treatment of infections
• For people with paralysis, there are some extra steps that are vital in preventing infection.
• Checking for pressure spots: For those who are use wheelchairs or aids, such as braces or splints, thorough skin checks for pressure spots is vital. Proper and frequent positioning and repositioning of people who are in bed for extended periods of time is essential to prevent pressure sores.
• Good technique for self-catheterization: Clean technique and monitoring urine for signs of infection are vital in reducing the risk of infection.
• Hygiene: Caregivers who must change briefs should always use gloves and wash their hands thoroughly after removing their gloves. They should also help the paralyzed individual to bathe carefully to make sure that their skin stays clean and is thoroughly dried.