Sepsis and Impaired Immune System

Your immune system protects you from many illnesses. It’s your defense system. It recognizes dangers to the body and fights bacteria, viruses, and other dangerous microbes to keep you healthy. An impaired – or weakened – immune system doesn’t protect you as well from infection.

Your immune system is made up of cells, proteins, and organs. For most people, it works well, although they still may get sick or contract an infection from time to time. This is why we get vaccinations against illnesses like tetanus, measles, and polio. Vaccines trick your body into thinking it already had the illness, making you immune to it. Other medications, like antibiotics, antivirals, antifungals, and antiparasitics help your body fight infections that do develop. These are all antimicrobials.

For a variety of reasons, many people are immunocompromised. Their immune system either doesn’t work well or not at all.  People with an impaired immune system are at higher risk of contracting infections, which increases their risk of developing sepsis. These infections may also be more severe.

Sepsis, which was often called blood poisoning, is the body’s life-threatening response to infection. Like strokes or heart attacks, sepsis is a medical emergency that requires rapid diagnosis and treatment.

Suggested Citation:
Sepsis Alliance. Sepsis and Impaired Immune System. 2024. https://www.sepsis.org/sepsisand/impaired-immune-system/

Updated January 19, 2024.

 

More About Impaired Immune Systems

Causes

There are several reasons for immunosuppression. Here are some:

Certain illnesses

Diseases like primary immune deficiency  make it difficult for people to fight infections. There are over 400 types of PI, according to the Centers for Disease Control and Prevention.

Cancer treatment

Some diseases, like cancer, are treated with chemotherapy. While chemotherapy can be quite effective in fighting the cancer cells, it can also destroy some of the body’s healthy cells, including those that help fight infection. People undergoing chemotherapy must avoid exposure to anything that could cause illness.

Some people with cancer and other serious illnesses require a bone marrow or stem cell transplant. This also makes it hard for your body to fight infection. To prepare people for such a transplant, they must undergo chemotherapy and sometimes radiation therapy. This will destroy cancer cells and depress the immune system, so the body doesn’t reject the transplant.

Organ transplants

Organ transplants are occurring more often now, allowing people to live longer and to improve their quality of life. However, the organ recipient’s body sees these new organs as invaders, so the immune system will try to fight them. To keep the body from rejecting the organ, people with organ transplants must take immunosuppressant drugs, or anti-rejection drugs. These drugs also can reduce the ability to fight other infections, such as colds, the flu, and more.

Splenectomy

Your spleen is a small organ in the upper part of your abdomen, near your stomach. It helps filter your blood and stores platelets and white blood cells, which fight infection. Certain illnesses can reduce how well your spleen works, such as sickle cell anemia. Technically, you can live without your spleen. People without spleens must be particularly careful to avoid exposure to anything that may cause an infection.

Other medications

Some medications are very useful in helping treat illnesses, even preventing death. However, they can also have serious side effects, like making you more susceptible to developing an infection. These include medicines like corticosteroids, such as prednisone, and TNF inhibitors, which may be prescribed for autoimmune diseases like rheumatoid arthritis or psoriasis.

Infection Prevention

An impaired immune system is a risk factor for infection. Infection prevention is vital. This includes proper hand washing, up-to-date vaccinations, and treating infections as soon as possible. Good nutrition is also essential. Not consuming enough nutrients for your needs, can lower your body’s ability to fight infection. If you are immunocompromised and suspect an infection, mention your immunocompromised status to the healthcare professionals. This will help them with your care.

Related Resources

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Kate Safford

The is the second (2nd) time I have survived sepsis!!! Leaving for vacation in May 2016, I was in the throes of a beginning UTI. (Sepsis and UTIs) CBC and UA w/culture completed at hospital lab and PCP notified of same. PCP started meds immediately as UTIs were typical, calling back on day 2 to change the meds. Day 3 of the trip, I developed a temp, and was woozy the next day. BP was 95/60, PCP sent me the ER. I explained to the ER doc that I have a primary immune deficiency-CVID (body doesn’t make antibodies to strep ... Read Full Story

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Rachel Davis

On August 3rd, 2021, I was admitted to the hospital with a breakthrough case of Covid-19. (Sepsis and COVID-19) I was fully vaccinated six months prior. My CT scan showed ground glass opacities in my right lower lung. I was blessed that my oxygen saturation was within normal limits. I was in the hospital for three weeks. Upon my discharge on 8/23/21, I stayed with a dear friend for approximately two weeks. Because of malnutrition and Covid, I believe, I was immunocompromised. I had leukopenia, low neutrophil and absolute neutrophil counts, and I was anemic. (Sepsis and Impaired Immune System) ... Read Full Story

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Annmarie Williams

Hi I am Annmarie. In 2010 I got a stomach bug and it’s changed my life. What ever the bug did affected my motility, then my gallbladder was removed. I ended up on IV nutrition in 2019. I have gastroparesis and likely severe sibo (small intestinal bacterial overgrowth). In 2020 January, I had sepsis, a bad pseudomonas infection. Luckily antibiotics worked. I then had another infection in April 2020 and a yeast infection after. (Sepsis and Bacterial Infections, Sepsis and Fungal Infections) Some how I fell pregnant with twins in June but didn’t know until September when I was 18 ... Read Full Story

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Pat Termini

A couple of hours before my wife Pat passed away in the ICU at her hospital, I said to her “Honey, if you have to go, I will respect your wishes, I want you to do what is best for you.” 2 hours later she passed away peacefully. I do know that she is in a much better place now, free of pain. Pat was allergic to opioid medications, which includes most everything except Tylenol. The pain from sepsis she endured those last 2 weeks must have been excruciating. Pat was a fighter. She fought squamous cell cancer for 11+ ... Read Full Story

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Alexa Foutch

I am a 16 time sepsis survivor. 3x septic shock survivor. What started as an asthma attack that put me on a ventilator, and I ended up vomiting which turned into aspiration pneumonia, however, I just kept getting sick after that though. I was septic with COVID and other illnesses. Come to find out I have primary ammagammabulemia. Because of sepsis I had to give up PTA school, am on supplemental oxygen 24/7 due to chronic respiratory failure, and have been on life support 14 times, I struggle every day with the after-effects of sepsis. I have been diagnosed with ... Read Full Story

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Impaired Immune System